Tatsufumi Nakamura Selected Research

Tropical Spastic Paraparesis (Tropical Spastic Paraplegia)

7/2021	Intravesical injection of onabotulinumtoxinA in neurogenic overactive bladder patients with human T-cell leukemia virus type 1-associated myelopathy: A single-institution case series.
4/2019	Efficacy of mirabegron for overactive bladder with human T cell lymphotropic virus-1 associated myelopathy.
1/2018	Prosultiamine for treatment of lower urinary tract dysfunction accompanied by human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis.
1/2018	Role of Integrin Signaling Activation on the Development of Human T Cell Leukemia Virus-1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis: Its Relationship to HTLV-1-Infected CD4+ T Cell Transmigrating Activity into the Tissues.
12/2017	The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline: possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis.
10/2017	Effectiveness of Daily Prednisolone to Slow Progression of Human T-Lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis: A Multicenter Retrospective Cohort Study.
1/2017	Tumor necrosis factor alpha inhibitors have no effect on a human T-lymphotropic virus type-I (HTLV-I)-infected cell line from patients with HTLV-I-associated myelopathy.
6/2014	Pentosan polysulfate treatment ameliorates motor function with increased serum soluble vascular cell adhesion molecule-1 in HTLV-1-associated neurologic disease.
8/2013	Efficacy of prosultiamine treatment in patients with human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: results from an open-label clinical trial.
1/2009	Disulfide-mediated apoptosis of human T-lymphotrophc virus type-I (HTLV-I)-infected cells in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis.

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Tatsufumi Nakamura Research Topics

Disease

16	Tropical Spastic Paraparesis (Tropical Spastic Paraplegia) 07/2021 - 04/2002
8	Spinal Cord Diseases 07/2021 - 05/2008
5	T-Cell Leukemia (Leukemia, T Cell) 07/2021 - 05/2008
4	Infections 01/2011 - 04/2002
3	Overactive Urinary Bladder (Overactive Bladder) 07/2021 - 01/2018
2	Autoimmune Diseases (Autoimmune Disease) 01/2021 - 01/2017
2	Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated) 01/2021 - 02/2005
2	Inflammation (Inflammations) 04/2015 - 04/2002
2	Myasthenia Gravis 01/2013 - 01/2003
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2021
1	Nocturia 04/2019
1	Ataxia (Dyssynergia) 01/2018
1	Neoplasms (Cancer) 12/2017
1	Multiple Sclerosis 12/2017
1	Communicable Diseases (Infectious Diseases) 01/2017
1	Phlebitis 06/2014
1	Thrombosis (Thrombus) 06/2014
1	Central Nervous System Diseases (CNS Diseases) 10/2009
1	Liver Cirrhosis (Hepatic Cirrhosis) 05/2008
1	Neurogenic Urinary Bladder (Bladder, Neurogenic) 02/2003
1	Churg-Strauss Syndrome (Allergic Angiitis) 02/2003
1	Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease) 10/2002
1	Kuru 10/2002
1	Stiff-Person Syndrome (Stiff Man Syndrome) 08/2002
1	Nervous System Diseases (Neurological Disorders) 04/2002

Drug/Important Bio-Agent (IBA)

3	prosultiamineIBA 01/2018 - 01/2009
3	LigandsIBA 12/2017 - 04/2002
2	IntegrinsIBA 01/2018 - 01/2008
2	CytokinesIBA 01/2017 - 12/2004
2	Proteins (Proteins, Gene)FDA Link 01/2017 - 10/2002
2	InterferonsIBA 06/2014 - 02/2005
2	Cholinergic ReceptorsIBA 01/2013 - 01/2003
2	AntigensIBA 01/2011 - 02/2005
2	Tacrolimus (Prograf)FDA LinkGeneric 10/2009 - 05/2008
2	SteroidsIBA 05/2008 - 02/2003
1	Type A Botulinum Toxins (Botox)FDA Link 07/2021
1	tocilizumab (atlizumab)FDA Link 03/2021
1	Antimalarials (Antimalarial Agents)IBA 01/2021
1	Chloroquine (Aralen)FDA LinkGeneric 01/2021
1	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 01/2021
1	Pharmaceutical PreparationsIBA 04/2019
1	mirabegronIBA 04/2019
1	CreatinineIBA 01/2018
1	Nerve Growth Factor (NGF)IBA 01/2018
1	Biomarkers (Surrogate Marker)IBA 01/2018
1	Adenosine Triphosphate (ATP)IBA 01/2018
1	Immune Checkpoint InhibitorsIBA 12/2017
1	Chemotactic FactorsIBA 12/2017
1	CC ChemokinesIBA 12/2017
1	Minocycline (Cyclops)FDA LinkGeneric 12/2017
1	Trans-Activators (Trans-Acting Factor)IBA 12/2017
1	Prednisolone (Predate)FDA LinkGeneric 10/2017
1	ChemokinesIBA 01/2017
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2017
1	ImmunosorbentsIBA 04/2015
1	EnzymesIBA 04/2015
1	Adrenal Cortex Hormones (Corticosteroids)IBA 06/2014
1	Heparinoids (Heparinoid)IBA 06/2014
1	Hormones (Hormone)IBA 06/2014
1	Pentosan Sulfuric Polyester (Pentosan Polysulfate)FDA Link 06/2014
1	AntibodiesIBA 01/2013
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2013
1	muskIBA 01/2013
1	LuciferasesIBA 01/2011
1	fucoidanIBA 01/2011
1	Polysaccharides (Glycans)IBA 01/2011
1	AutoantibodiesIBA 10/2009
1	allithiamineIBA 01/2009
1	Sulfhydryl Compounds (Thiols)IBA 01/2009
1	allicinIBA 01/2009
1	DisulfidesIBA 01/2009
1	Thiamine (Aneurin)FDA Link 01/2009
1	Interferon-alpha (Interferon Alfa)IBA 05/2008
1	Monomeric GTP-Binding ProteinsIBA 01/2008
1	Interleukin-2 Receptors (IL 2 Receptor)IBA 01/2007
1	p38 Mitogen-Activated Protein KinasesIBA 02/2005
1	Messenger RNA (mRNA)IBA 12/2004
1	Complement System Proteins (Complement)IBA 01/2003
1	PrionsIBA 10/2002
1	Intravenous Immunoglobulins (IVIG)FDA Link 08/2002
1	Interferon-gamma (Interferon, gamma)IBA 04/2002
1	Interleukin-12 (IL 12)IBA 04/2002
1	Interleukin-12 Receptors (Interleukin 12 Receptor)IBA 04/2002
1	CD40 Ligand (CD40L)IBA 04/2002
1	Sialyl Lewis X AntigenIBA 04/2002
1	P-SelectinIBA 04/2002

Therapy/Procedure

4	Therapeutics 07/2021 - 08/2002
1	Injections 07/2021
1	Intravesical Administration 07/2021
1	Aftercare (After-Treatment) 01/2018
1	Immunotherapy 12/2017
1	Liver Transplantation 05/2008
1	Plasma Exchange 08/2002